Mai Cara is a small family run hotel which is an easy walk from the Santa Maria Novella train station. The location is a 10 minutes walk to the Accademia, and maybe 20 minutes to Uffizi. Lots of stores nearby as well (very good leather stores).
The room was nice, clean, and quiet. The staff were very helpful, especially the young daughter who managed English very well. They organized a laundry day for us, as well as a massage in the spa.